To further develop outstanding cancer research, the UZH has established the competitive CRC funding program supporting multidisciplinary, translational research projects of scientists and physician-scientists. The program is a pivotal instrument for the strategic development of the CRC ZURICH and will strengthen the CRC research programs. Within the frame of the first call, seven projects - each jointly coordinated by one UZH and one USZ investigator - are funded with 140.000 CHF p.a. for 2 years. They all aim to translate novel cancer research discoveries into clinical application and to ultimately improve cancer patient care. Please click here for an overview of funded projects.
Tumor Therapy of the Future
An interdisciplinary team of chemists, biochemists, geneticists and molecular biologists at UZH, three of them CRC members - Christian Mosimann, Amedeo Caflish and Tuncay Baubec together with Cristina Nevado, have been awarded a SNSF Sinergia grant (3.2 Million CHF).This collaboration will enable research into new epigenetic approaches for treating Acute Myeloid Leukemia (AML), a dangerous cancer of the blood cells. Together they’re addressing the question of how certain enzymes switch genes in the chromosome on and off. MORE
Human blood cells, with acute myeloid leukemia cells colored red. (Picture: NIH)
Loss of Cilia Leads to Melanoma
Most cells in the human body have a cilium, a slender cell protuberance that picks up signals from the cell’s external environment. A team of researchers led by Lukas Sommer, professor at the Institute of Anatomy at the University of Zurich (UZH), has now shown that these fine sensory antennae play a key role in the formation of melanoma. When cilia are prevented from developing in benign pigment cells, the cells degenerate and develop an aggressive form of melanoma. MORE
Melanoma cells (blue/green) with cilium (light green). Image: Daniel Zingg, Netherlands Cancer Institute
Daniel Zingg, Julien Debbache, Rodrigo Peña-Hernández, Ana T. Antunes, Simon M. Schaefer, Phil F. Cheng, Dario Zimmerli, Jessica Haeusel, Raquel R. Calçada, Eylul Tuncer, Yudong Zhang, Raphaël Bossart, Kwok-Kin Wong, Konrad Basler, Reinhard Dummer, Raffaella Santoro, Mitchell P. Levesque, and Lukas Sommer. EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell, June 28, 2018. DOI: 10.1016/j.ccell.2018.06.001