CRC Funding Program

To further develop outstanding cancer research, the UZH and Medical Faculty have established the competitive CRC funding program (CHF 4.9 Mio., 2018-2021) supporting multidisciplinary, translational research projects of scientists and physician-scientists at the CCCZ.

Principal Investigators from the CCCZ are invited to be part of an innovative, interdisciplinary research team helping to rapidly transfer basic science discoveries into clinical application. To qualify for support, research projects must involve at least one scientist and one physician-scientist. It is encouraged that both partners are CRC members; at least one of the partners must be CRC member.

Competitive funding is available in the form of fellowships covering the salary or protected research time of outstanding scientists and physician-scientists engaged in collaborative projects between groups from preclinical and clinical fields. Currently, five 2-year fellowships will be funded every year.

UZH NEWS
Read more about the 2018 CRC Call and the CCCZ.

FUNDED CRC PROJECTS - 1st Call (2018-2020)

The CRC funding program is a pivotal instrument for the strategic development of the CRC ZURICH and will strengthen the CRC research programs. Within the frame of the first call (2018), seven projects were recommended for funding by a panel of external renowned scientists. We are very pleased to announce that two of the seven projects are funded by the ISREC Foundation (please see table below).

UZH NEWS
Read more about the CRC funding program and the CCCZ.

PRINCIPLE INVESTIGATORS	PROJECT TITLE
Prof. Dr. Anne Müller Institute for Molecular Cancer Research University of Zurich Prof. Dr. med. Thorsten Zenz Department of Hematology and Oncology University Hospital Zurich	Targeting the tumor microenvironment in B-cell malignancies: exploiting patient-derived xenografts for the rational pre-clinical testing of interventions that result from drug and genetic screening MORE
Prof. Dr. Martin Pruschy Research Unit for Applied Radiobiology, Department of Radiation Oncology, University Hospital Zurich Prof. Dr. med. Onur Boyman Clinical lmmunology, University of Zurich and Department of lmmunology, University Hospital Zurich	Alternative combined radioimmunotherapy to overcome treatment-related resistances MORE
Prof. Dr. Massimo Lopes Institute of Molecular Cancer Research University of Zurich Prof. Dr. med. Achim Weber Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich	Deciphering tumorigenesis driven by replication-associated DNA damage MORE *Funded by the ISREC Foundation
Prof. Dr. Michael O. Hottiger Department of Molecular Mechanisms of Disease University of Zurich PD Dr. med. Peter Schraml Department of Pathology and Molecular Pathology University Hospital Zurich	Validation of mono-ADP-ribosylated proteins as diagnostic and prognostic tool in oncology MORE
Prof. Dr. Maries van den Broek Institute of Experimental Immunology University of Zurich Prof. Dr. med. Lukas Flatz Senior Consultant in Dermato-oncology, Department of Oncology and Department of Dermatology Kantonsspital St.Gallen	Tertiary lymphoid structures in metastatic melanoma and non-small cell lung cancer tissues as predictive markers for the outcome of checkpoint inhibitor treatment MORE
Prof. Dr. Mitchell Levesque Department of Dermatology University Hospital Zurich and University of Zurich Prof. Dr. med. Matthias Guckenberger Department for Radiation Oncology University Hospital Zurich	Immuno-Radiomics as a novel prognostic and predictive biomarker in malignant melanoma treated with immune checkpoint inhibition - a multi-systems approach MORE
Prof. Dr. Lukas Sommer Institute of Anatomy University of Zurich Prof. Dr. med. Reinhard Dummer Department of Dermatology University Hospital Zurich	Investigating the functional role of cellular phenotypes in melanoma targeted therapy MORE *Funded by the ISREC Foundation

FUNDED CRC PROJECTS - 2nd Call (2019-2021)

Within the frame of the second call, six projects were recommended for funding by a panel of external renowned scientists.

PRINCIPLE INVESTIGATORS	PROJECT TITLE
Prof. Dr. Konrad Basler Institute of Molecular Life Sciences University of Zurich Prof. Dr. med. Dr. phil. Gerhard Rogler Department of Gastroenterology and Hepatology University Hospital Zurich	Decrypting the crosstalk between a developing colorectal tumor and its micro-environment MORE
Prof. Dr. Raffaella Santoro Department of Molecular Mechanisms of Disease University of Zurich Prof. Dr. med Dr. sc. nat. Jean-Pierre Bourquin Children’s Research Center, Leukemia Research Unit Balgrist Campus Childrens’ Hospital Zurich	Targeting the transcriptional network architecture driven by the oncogenic TCF3-HLF Fusion MORE
Prof. Dr. Tuncay Baubec Department of Molecular Mechanisms of Disease, Laboratory of Systems Biology of Gene Regulation University of Zurich Prof. Dr. med. Michael Weller Department of Neurology, Laboratory of Molecular Neurooncology University Hospital and University of Zurich	An integrative approach to characterize and exploit the epigenetic landscape in glioblastoma MORE
Prof. Dr. Lubor Borsig Institute of Physiology University of Zurich Prof. Dr. med. Michael Scharl Department of Gastroenterology and Hepatology University Hospital Zurich	Butyrate-producing bacteria ameliorate CRC tumorigenesis through modulation of immune responses MORE
Prof. Dr. Jacob Corn Department of Biology ETH Zürich Prof. Dr. med. Markus G. Manz Department of Medical Oncology and Hematology University Hospital Zurich and University of Zurich	Human clonal hematopoiesis and its effect on human tumor growth in humanized mice MORE
Prof. Dr. Burkhard Becher Institute of Experimental Immunology University of Zurich PD Dr. med. Alexandre Theocharides Department of Medical Oncology and Hematology University Hospital Zurich	The immune environment of acute myeloid leukemia MORE

FUNDED CRC PROJECTS - 3rd Call (2020-2021)

Within the frame of the third call, four projects were recommended for funding by a panel of external renowned scientists.

PRINCIPLE INVESTIGATORS	PROJECT TITLE
Prof. Dr. sc. nat. Matthias Altmeyer Department of Molecular Mechanisms of Disease, University of Zurich Prof. Dr. med. Daniel Fink Gynecological Cancer Center, Department of Gynecology, University Hospital Zurich	TRIP12 AS DETERMINANT OF PARP INHIBITOR THERAPY
Prof. Dr. Anne Müller Institute of Molecular Cancer Research, University of Zürich Prof. Dr. med. Achim Weber Institute of Pathology and Molecular Pathology, University Hospital Zurich	MUTATIONS IN R-LOOP METABOLISM GENES AS DRIVERS OF GASTRIC CARCINOGENESIS
Prof. Dr. Bernd Bodenmiller Department of Quantitative Biomedicine, University of Zurich Prof. Dr. med. Holger Moch Institute of Pathology and Molecular Pathology, University Hospital Zurich	TUMOR-IMMUNE PHENOTYPES IN DIFFERENT RENAL CELL CARCINOMA GENOTYPES
Prof. Dr. Maries van den Broek Institute of Experimental Immunology, University of Zurich Prof. Dr. med. Reinhard Dummer Dept. of Dermatology, University Hospital Zurich	IDENTIFYING CLINICAL RESPONSE-RELEVANT, T-VEC-INDUCED CHANGES IN THE TUMOR MICRO-ENVIRONMENT

CRC FELLOWS

FELLOW Christophe Boudesco, PhD CV	PROJECT Targeting the tumor microenvironment in B-cell malignancies: exploiting patient-derived xenografts for the rational pre-clinical testing of interventions that result from drug and genetic screening MORE MENTORS Prof. Dr. Anne Müller Institute for Molecular Cancer Research, UZH Prof. Dr. med. Thorsten Zenz Department of Hematology and Oncology, USZ
FELLOW Carmen Yong, PhD CV	PROJECT Alternative combined radioimmunotherapy to overcome treatment-related resistances MORE MENTORS Prof. Dr. Martin Pruschy Research Unit for Applied Radiobiology, Department of Radiation Oncology, USZ Prof. Dr. med. Onur Boyman Department of lmmunology, USZ
FELLOW Laure-Alix Clerbaux, PhD CV	PROJECT Deciphering tumorigenesis driven by replication-associated DNA damage MORE Funded by the ISREC Foundation MENTORS Prof. Dr. Massimo Lopes* Institute of Molecular Cancer Research, UZH Prof. Dr. med. Achim Weber Department of Pathology and Molecular Pathology, USZ
FELLOW Fabio Aimi, PhD	PROJECT Validation of mono-ADP-ribosylated proteins as diagnostic and prognostic tool in oncology MORE
FELLOW Oltin T. Pop, MD, PhD CV	PROJECT Tertiary lymphoid structures in metastatic melanoma and non-small cell lung cancer tissues as predictive markers for the outcome of checkpoint inhibitor treatment MORE MENTORS Prof. Dr. Maries van den Broek Institute of Experimental Immunology, UZH Prof. Dr. med. Lukas Flatz Department of Oncology and Department of Dermatology, Kantonsspital St.Gallen, UZH
FELLOW Simon Burgermeister	PROJECT Immuno-Radiomics as a novel prognostic and predictive biomarker in malignant melanoma treated with immune checkpoint inhibition - a multi-systems approach MORE MENTORS Prof. Dr. Mitchell Levesque, Department of Dermatology, USZ Prof. Dr. med. Matthias Guckenberger, Department for Radiation Oncology, USZ
FELLOW Jelena Vasilevska, PhD CV	PROJECT Investigating the functional role of cellular phenotypes in melanoma targeted therapy MORE Funded by the ISREC Foundation MENTORS Prof. Dr. Lukas Sommer, Institute of Anatomy, UZH Prof. Dr. med. Reinhard Dummer*, Department of Dermatology, USZ
FELLOW Ana Montalban-Arques, PhD CV	PROJECT Butyrate-producing bacteria ameliorate CRC tumorigenesis through modulation of immune responses MORE
FELLOW Valdemar Priebe, PhD CV	PROJECT Targeting the transcriptional network architecture driven by the oncogenic TCF3-HLF Fusion MORE MENTORS Prof. Dr. Raffaella Santoro Department of Molecular Mechanisms of Disease University of Zurich Prof. Dr. med Dr. sc. nat. Jean-Pierre Bourquin Children’s Research Center, Leukemia Research Unit Balgrist Campus Childrens’ Hospital Zurich
FELLOW Hassan Fazilaty, PhD CV	PROJECT Decrypting the crosstalk between a developing colorectal tumor and its micro-environment

CRC Membership

Basic and physician.scientists of UZH, USZ, ETH and other Swiss Universities can apply to become a CRC member by submitting the completed membership application form to Maja Zenz. Applicants will usually be informed within a month.

MEMBERSHIP CRITERIA

Faculty member of the Medical Faculty, the Faculty of Science or Vetsuisse Faculty OR having the right to confer a PhD at the Faculty of Science. Faculty members of ETH or other Swiss universities may be admitted, if this is supported by three CRC members; however, such external members are not eligible to receive UZH funding - for now.

AND
Having an own research grant from the SNSF, OncoSuisse, European Community or NIH.

	MEMBERS' MEETINGS
Up-coming meetings will be announced in the near future. PAST MEETINGS 2019 24-26.3.2019 - 2019 Scientific Retreat of the Comprehensive Cancer Center Zurich 24.3.2019 - CRC Members Assembly

Current Overview of CRC Members

	CRC Members A-F
Matthias Altmeyer Konrad Basler Tuncay Baubec Martin Baumgartner Burkhard Becher Felix Beuschlein Bernd Bodenmiller Beat Bornhauser Lubor Borsig Jean-Pierre Bourquin Onur Boyman Amedeo Caflisch Pierre-Alain Clavien Jacob Corn Michael Detmar Raghvendra Dubey Reinhard Dummer Daniel Eberli Daniel Fink Lukas Flatz

	CRC Members G-K
Kerstin Gari Urs Greber Matthias Guckenberger Alex Hajnal Jason Holland Michael Hottiger Pavel Janscak

	CRC Members L-R
Kuno Lehmann Mitch Levesque Massimo Lopes Markus Manz Giancarlo Marra Holger Moch Andreas Moor Christian Mosimann Anne Müller Christian Münz Hanspeter Nägeli Darius Neri Felix Niggli Cesar Nombela-Arrieta Lorenza Penengo Andreas Plückthun Martin Pruschy Gerhard Rogler

	CRC Members S-Z
Raffaella Santoro Alessandro Sartori Beat Schäfer Michael Scharl Roger Schibli Isabelle Schmitt-Opitz Lukas Sommer Rolf Stahel Christian Stockmann Manuel Stucki Tullio Sulser Maries van den Broek Achim Weber Sabine Werner Walter Weder Michael Weller Lynn Wong